Voprosy meditsinskoi khimii (ISSN 0042-8809)

The genotype analysis of the biochemical status at the significant dozes irradiated people

   
Telnov V.I., Zhuntova G.V.
PubMed Id: 9916264
Year: 1998 vol: 44  issue:5  pages: 479-484
Abstract: 416 workers of the enterprise of a nuclear industry aged from52 to 78 years exposed to chronic influence of external gamma -irradiation in summary dozes 1,0-7,56 Gy and plutonium-239incorporation, (in 32,3 % of cases exceeding the allowable limit)were studied. A correlation between a complex of 26 biochemicaland immunochemical parameters and the radiating factors wasinvestigated at different haptoglobin genotypes (Hp). It wasestablished, that the greatest number of changes of biochemicalparameters related to radiating influence, was observed at thepeople with a genotype Hp 2-2 (7 parameters), to a lesser degree- at a genotype Hp 2-1 (5 parameters) and in some more smallerdegree - at a genotype Hp 1-1 (4 parameters). All investigatedpeople with a genotype 2-2 were characterised by increase ofserum protein entropy.
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Reference: Telnov V.I., Zhuntova G.V., The genotype analysis of the biochemical status at the significant dozes irradiated people, Voprosy meditsinskoi khimii, 1998, vol: 44(5), 479-484.
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