Voprosy meditsinskoi khimii (ISSN 0042-8809)

Gamma-aminobutyric acid content in blood: a "peripheralindicator" of the state of central neuromediator system

   
Mishunina T.M.
PubMed Id: 10599136
Year: 1998 vol: 44  issue:6  pages: 511-519
Abstract: The review summarized data on contents of the main inhibitoryneurotransmitter of the central nervous system:gamma-aminobutyric acid (GABA) in blood of normal animal andhumans, in blood of different animal species under experimentaleffects and modelling of pathological states, as well as in humanblood in the presence nervous and endocrine diseases.Determination of GABA concentration in blood, taking into accountthe accessibility of study object, absence of significant sex,age, seasonal, diurnal fluctuations, as well as stability ofamino acid level during the laboratory assay procedure, may beuseful for the study of central neuromediator mechanisms, andallows, usung representative samples and corresponding groups ofcomparison, to obtain data on disturbances of functional state ofthe GABAergic system under conditions of brain pathology.
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Reference: Mishunina T.M., Gamma-aminobutyric acid content in blood: a "peripheralindicator" of the state of central neuromediator system, Voprosy meditsinskoi khimii, 1998, vol: 44(6), 511-519.
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