Voprosy meditsinskoi khimii (ISSN 0042-8809)

Increased level of lipid peroxidation products in blood serum as a biochemical marker of associated pancreatitis in gallstone disease

   
Dudnik L.B.
PubMed Id: 10599144
Year: 1998 vol: 44  issue:6  pages: 571-575
Abstract: Serum concentration of two products lipid peroxidation (LPO)of - conjugated dienes and dienketones - was assessed in 71patients with exacerbation and remission of chronic pancreatitis,uncomplicated gallstone disease and with combinated pathology ofpancreas and biliary tracts and in 100 healthy persons. Duringexacerbation of pathologic process in pancreas with the differentethiolgy of disease strong intensification of LPO occurs, but inperiod of remission LPO markers were found to be close to thosein control. Postoperative complications and severe outcome inpatients with gallstone disease are associated with a significantincrease in LPO level in serum before reoperation. Routineclinical data in these patients detect no symptom of pancreaspathology. This finding evidenced that concentration of LPOproducts in the sera of patients with gallstone disease may be ofgreat significance for diagnosis of associated pancreatitis andearly predictor of outcome.
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Reference: Dudnik L.B., Increased level of lipid peroxidation products in blood serum as a biochemical marker of associated pancreatitis in gallstone disease, Voprosy meditsinskoi khimii, 1998, vol: 44(6), 571-575.
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