Voprosy meditsinskoi khimii (ISSN 0042-8809)

Alteration of lymphocyte and erythrocyte membrane microviscosity in the blood of tumor patients

   
Goroshinskaya I.A., Golotina L.Yu., Gorlo E.I., Rovda T.A., Bordushkov YU.N.
PubMed Id: 10205829
Year: 1999 vol: 45  issue:1  pages: 53-57
Abstract: Lymphocyte and erythrocyte membrane microviscosites oflipid-protein contact zones and lipid bilayer in blood ofpatients with gastric, urinary bladder and ovary cancers wereinvestigated in comparison with healthy volunteers by means ofcoefficients of eximerization of fluorescent probe pyrene. Thedecrease of membrane fluidity (i.e. the increase ofmicroviscosity) was revealed in blood cell membranes of patientswith diffuse cancers of studied localizations. In the case ofovary cancer membrane fluidity decreased significantly only inpatients with ascite form of the disease. The most pronouncedincrease of microviscosity was observed in lymphocytes andespecially in erythrocytes of practically incurable patients.Interrelationship between microviscosity and other processes thatinfluence on structural properties of membranes under malignancyand their functional role are discussed.
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Reference: Goroshinskaya I.A., Golotina L.Yu., Gorlo E.I., Rovda T.A., Bordushkov YU.N., Alteration of lymphocyte and erythrocyte membrane microviscosity in the blood of tumor patients, Voprosy meditsinskoi khimii, 1999, vol: 45(1), 53-57.
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