Voprosy meditsinskoi khimii (ISSN 0042-8809)

Lipid indexes of the skin, the cerebellum and the medulla oblongatain rats during water-immersion stress

   
Gribanov G.A., Kostyuk N.V., Abramov Yu.V., Bykov V.A., Rebrov L.B., Volodina T.V., Pertsov S.S.
PubMed Id: 10378301
Year: 1999 vol: 45  issue:2  pages: 131-135
Abstract: The influence of short-form water immersion stress of rats on lipidsin the skin, the cerebellum and the medulla oblongata was studied. The level of totallipids and absolute and relative contents of the main lipid fractions (phospholipids,nonesterified cholesterol, free fatty acids, triglycerides, and cholesterol esters) weremeasured. Stress induced delayed changes of the lipid component of the skin. The firstsignificant changes of lipid fractions were only observed 20 h later after the stressprocedure. These changes were retained (being at nearly constant levels) till the end ofthe second day. The decrease in contents of total lipids and esterified cholesterol wasrevealed in the cerebellum of stressed rats (in comparison to these levels in controlrats). These results suggest the involvement of cholesterol metabolic system in the stressreaction. The content of total lipids decreased also in the medulla oblongata. However,levels of the main lipid fractions changed differently. The content of diglyceridesincreased and the content of cholesterol decreased. The data obtained suggest thatdegradation of triglycerides is the principle pathway of metabolic conversions of lipids.Free fatty acids formed during these processes are probably involved in the synthesis ofphospholipids and cholesterol esters. The data indicate absolutely different mechanisms ofinterrelations between individual lipid fractions in the brain regions studied. Variousroles of the brain structures in the stress response of the body may account for thedifferences revealed.
Download PDF:
Reference: Gribanov G.A., Kostyuk N.V., Abramov Yu.V., Bykov V.A., Rebrov L.B., Volodina T.V., Pertsov S.S., Lipid indexes of the skin, the cerebellum and the medulla oblongatain rats during water-immersion stress, Voprosy meditsinskoi khimii, 1999, vol: 45(2), 131-135.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)