Voprosy meditsinskoi khimii (ISSN 0042-8809)

Vitamin b1 and b2 metabolism in phenylketonuric patients

   
Kodentsova V.M., Vrzhesinskaya O.A., Denisova S.N., Sprichev V.B.
PubMed Id: 10378305
Year: 1999 vol: 45  issue:2  pages: 150-157
Abstract: Vitamin level in blood plasma and erythrocytes and a rate of urinaryexcretion of vitamin metabolites were analised in children suffering from phenylketonuria.it has been shown that vitamin B1 metabolism and therefore the criteria of theadequate sufficiency with this vitamin does not differ from those for healthy people.Increased riboflavin urinary excretion under its decreased plasma and erythrocyte levelshas been demonstrated for PKU children. In consequence of this the indexes of sufficiencysignificantly differ from those of the healthy adequatly supplied with this vitaminchildren and are equal to 4 ng of riboflavin per 1 ml of blood plasma and its urinaryexcretion more than 50 mg/h. The necessity for the redetermination of vitamin B2diet optimal content under this disease and its biochemical validation are discussed.
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Reference: Kodentsova V.M., Vrzhesinskaya O.A., Denisova S.N., Sprichev V.B., Vitamin b1 and b2 metabolism in phenylketonuric patients, Voprosy meditsinskoi khimii, 1999, vol: 45(2), 150-157.
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