Voprosy meditsinskoi khimii (ISSN 0042-8809)

Fibrinolytic activity of urine in chronic glomerulonephritis and amyloidosis

   
Podorolskaya L.V., Andreenko G.V., Polyantseva L.R., Bumblyte I.D.
PubMed Id: 10378306
Year: 1999 vol: 45  issue:2  pages: 158-164
Abstract: Correlative interconnections between plasminogen activator (PA)activity (fibrin plate method) and level of urokinase antigen (Ag UAP) and tissue PAantigen (Ag TAP) in urine and blood (ELISA) were studied in 60 patients with chronicglomerulonephritis (CGN) and 38 patients with amyloidosis. the high degree of positivecorrelation between blood and urine initial PA activity and Ag UAP content was found. Thissuggests the possible leading role of UAP in formation of the basal fluctuations offibrinolytic activity in blood and urine. high degree of correlation - r=+0,84 andp<0,001 - was found between blood Ag UAP and urine Ag TAP in amyloidosis only. Thefunctional protein loading probe revealed great importance of high urine and blood APactivity in realizing of ultrafiltration renal process - in CGN and amyloidosis.
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Reference: Podorolskaya L.V., Andreenko G.V., Polyantseva L.R., Bumblyte I.D., Fibrinolytic activity of urine in chronic glomerulonephritis and amyloidosis, Voprosy meditsinskoi khimii, 1999, vol: 45(2), 158-164.
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