Abstract: Gene therapy of vascular diseases represents a new perspective field inthe modern biomedical science. It is based on the employment of genetic constructions formedical treatment. The paper reviews major directions in gene therapy of vasculardiseases: inhibition of proliferative processes in the vascular wall; administration intothe elements of vascular wall of genes responsible for nitric oxide synthesis;normalisation of blood pressure regulatory system; synthesis of thromboembolic factors andanticoagulants; gene therapy of atherosclerosis; revascularisation of ischaemic myocardiumand inhibition of tumor vascularisation.
1. Culver К. W. (1994) Gene Therapy. A Handbook for Physicians. N.Y. Mary Ann Liebert Inc. Publishers, pp. 1-117. Scholar google search
2. Wolff J.A., Lederberg J. (1993) In: Gene theraputics. Methods and Application of Direct Gene Transfer (J.A.Wolff, Ed). Birkhauser, pp. 3-25. Scholar google search
6. Fox J.C. (1998) In: Stem cell biology and gene therapy. (P.J.Quesenberry, G.S.Stein, B.G.Forget, S.W.Weissman, Eds) Wiley-Liss, 471-502 Scholar google search
7. Laitinen M., Pakkaren Т., Donetti E., Baetta R., Luoma J., Lehtolainen P., Viita H., Agrawal R., Miyanohara A., Friedmann Т., Risau W., Martin J.F., Soma M. (1997) Human Gene Therapy, 8, 1645-1650, Scholar google search
8. Hall F.L., Gordon EM., Wu L. Zhu N.L., Skotzko M.J., Starnes V.A., Anderson W.F. (1997) Human Gene Therapy, 8, 2183-2192. Scholar google search
9. Van Belle E., Maillard L., RivardA., Farbe J-E., Couffinhal Т., Kearney M., Branellec D., Feldman L.J., Walsh K., Isner J.M. (1998) Human Gene Therapy, 9, 1013-1024, Scholar google search
10. Back S., March K.L. (1998) Circulation Research, 82, 295-305. Scholar google search
11. De Young M.B., Dichek D.A. (1998) Circulation Research, 82, 306-313. Scholar google search
12. Fox J.C, Shanley J.R. (1996) J.Biol.Chem., 271, 12578-12584. Scholar google search
29. 1st Annual meeting of the American Society of Gene Therapy. (1998). Seattle, Washington. American Society Of Gene Therapy, Thorefare, New Jersey, USA. Scholar google search
34. Griscelli F., Li H, Bennaceur-Griscelli A., Soria J., Opolon P. Soria C, Perricaudet M., Yeh P., Lu H. (1998) Proc. Natl. Acad. Sci.USA, 95, 6367-6372. Scholar google search
35. Sato T.N. (1998) Proc. Natl. Acad. Sci.USA, 95, 5843-5844. Scholar google search
36. Schneider D.B., Fly C.A., Dichek D.A., Gear R.L. (1998) Human Gene Therapy., 9, 815-821. Scholar google search
