Voprosy meditsinskoi khimii (ISSN 0042-8809)

Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement

   
Voitenko N.N., Barykina N.N., Kolpakov V.G.
PubMed Id: 10432556
Year: 1999 vol: 45  issue:3  pages: 216-222
Abstract: Rats genetically predisposed (PM+) and non-predisposed (PM-) to pendulum movement (spontaneous nystagm) were studied at different age. In old PM+ and PM- rats the brain MAO-A activity did not differ, unlike between young PM+ and PM- rats. In old PM+ and PM- rats, brain stem MAO-A activity was higher than in young ones. Actinomycin D lowered brain stem MAO-A activity in PM+ and PM- rats. In the absence of actinomycin D, stress elevated MAO-B activity in the brain stem of PM- rats, and a preliminary actinomycin D administration prevent the MAO-B activating effect of stress. Possible differences in MAO-A and MAO-B regulation at transcription level in PM+ and PM- are discussed
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Reference: Voitenko N.N., Barykina N.N., Kolpakov V.G., Brain monoamine oxidase in ageing of rats genetically predisposed to pendulum movement, Voprosy meditsinskoi khimii, 1999, vol: 45(3), 216-222.
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