Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure

   
Lishmanov Yu.B., Naryznaya N.V., Maslov L.N.
PubMed Id: 10432558
Year: 1999 vol: 45  issue:3  pages: 227-231
Abstract: Acute cold exposure of organism (4 hours at -20 degrees C) inhibits myocardial protein synthesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5, Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and decreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate 'anabolic' effect of dalargin. 'Anabolic' effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion
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Reference: Lishmanov Yu.B., Naryznaya N.V., Maslov L.N., Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure, Voprosy meditsinskoi khimii, 1999, vol: 45(3), 227-231.
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