Voprosy meditsinskoi khimii (ISSN 0042-8809)

Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus

   
Korovkin B.F., Belayeva N.F., Kraevoy C.A., Golubev M.A., Gorodetsky V.K., Markova M.S., Kolchenko O.L.
PubMed Id: 10432559
Year: 1999 vol: 45  issue:3  pages: 232-237
Abstract: Variation of fructose 2,6-bisphosphate (F-2,6-P2) content inthe peripheral blood lymphocytes of patients with diabetes mellitus (type II) wasinvestigated.The 2.5-fold increase of F-2,6-P2 level compared witn to thecontrol group was observed in untreated patients with early stage of the disease. Inpatients using of peroral antidiabetic drugs that corrected diabetes F-2,6-P2level was approach ed to the normal one. At the same time F-2,6-P2 contentdecreases in patients with severe (noncorrected) diabetes mellitus. The possiblemechanisms of regulation of lymphocyte F-2,6-P2 concentration in normalconditions and diabetes mellitus are discussed.
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Reference: Korovkin B.F., Belayeva N.F., Kraevoy C.A., Golubev M.A., Gorodetsky V.K., Markova M.S., Kolchenko O.L., Variation of fructose 2.6-bisphosphate content in peripheral blood lymphocytes of patients with diabetes mellitus, Voprosy meditsinskoi khimii, 1999, vol: 45(3), 232-237.
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