Voprosy meditsinskoi khimii (ISSN 0042-8809)

Loss of serotonin transporter immunoreactive 43-kDa protein in platelets from patients with somatoform disorders correlates with depressive symptoms

   
Belous A.R., Ramamoothy S., Blakely R.D., Factor M.I., Lozier R.Y., Dupin A.M., Bechiashvili A.G., Brusov O.S., Morozova M.A.
PubMed Id: 10432563
Year: 1999 vol: 45  issue:3  pages: 256-262
Abstract: To elucidate the role of serotonin transporter (SERT) protein as acandidate target for somatoform disorders (SD), we have performed an association study ofthe SERT immunoreactive (IR-SERT) protein level by using site-specific antibodies directedat C-terminus epitope poorly conserved among other cotransporters. 22 patients who metDSM-IY criteria for SD and 32 healthy volunteers matched in sex and age participated inthe study. In platelets from all healthy donors, IR-SERT proteins migrates as a diffuseband between 75 and 102 kDa and a major sharper band at 43 kDa. We revealed almostcomplete disappearance of platelet 43 kDa IR-SERT protein in all patients with SD. Allpatients were rated with Hamilton Depressive Rating Scale (HDRS). There were found asignificant negative correlation between residual IR-SERT 43kDa protein level and HDRSScores [r= -0.83; P<0.000001]. These findings suggest that a biosynthetic or processingabnormality may exist in SERTs in the affected population and may reflect the dysfunctionof serotonin neurotransmission in CNS.
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Reference: Belous A.R., Ramamoothy S., Blakely R.D., Factor M.I., Lozier R.Y., Dupin A.M., Bechiashvili A.G., Brusov O.S., Morozova M.A., Loss of serotonin transporter immunoreactive 43-kDa protein in platelets from patients with somatoform disorders correlates with depressive symptoms, Voprosy meditsinskoi khimii, 1999, vol: 45(3), 256-262.
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