Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antioxidant enzyme activities in liver and brain decrease in early diabetes stages and this decrease is related with the nmda receptor function

   
Kosenko E.A., Kaminsky A.Y., Kaminsky Y.G.
PubMed Id: 10547879
Year: 1999 vol: 45  issue:4  pages: 304-308
Abstract: Antioxidant enzyme activities in rat liver and forebrain and the effectof the MK-801 administration on these activities were estimated on 6th day ofalloxan-induced diabetes. The catalase, superoxide dismutase, glutathione reductase, andglutathione peroxidase activities of cytosolic fractions from both liver and forebrainwere shown to decrease significantly in prediabetic rats, and these alterations werevirtually prevented by the course of MK-801 administration. The results suggest that thesuppression of antioxidant enzymes can be the primary biochemical disturbance in diabetesprogression and that glutamate NMDA receptors can be involved in the molecular mechanismunderlying this condition.
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Reference: Kosenko E.A., Kaminsky A.Y., Kaminsky Y.G., Antioxidant enzyme activities in liver and brain decrease in early diabetes stages and this decrease is related with the nmda receptor function, Voprosy meditsinskoi khimii, 1999, vol: 45(4), 304-308.
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