Voprosy meditsinskoi khimii (ISSN 0042-8809)

Protective effect of different form superoxide dismutase on the plasma membrane phospholipid composition of hepatocyte and adipocyte and on the blood lipoprotein composition in hemorrhagic shock in cats

   
Leskova G.F.
PubMed Id: 10635533
Year: 1999 vol: 45  issue:5  pages: 389-397
Abstract: Using a model of hemorrhagic shock, the possibility of protection byCu,Zn-superoxide dismutase (SOD) of the phospholipid bilayer of plasma membranes ofhepatocytes and adipocytes as well as of the blood lipoproteins was studied. SOD (5mg/kg), injected 30 min after the onset of bleeding, efficiently prevented changes in thephospholipid bilayer of hepatocytic plasma membranes in cats. Simultaneous injection ofSOD partly restored the concentration of different classes of phospholipids in plasmamembranes of mesenterial fatty tissue adipocytes altered by shock. When incorporated intoliposomes, SOD exerted a weaker corrective effect on the phospholipid composition ofhepatocytic plasma membranes in animals with hemorrhagic shock and simultaneously produceda membrane-stabilizing effect on adipocytes. In contrast to pure SOD (which had no effecton the lipoprotein composition of the blood in animals with hemorrhagic shock),SOD-containing liposomes decreased the amount of chylomicrons and very low densitylipoproteins in the venous blood of central vessels.
Download PDF:
Reference: Leskova G.F., Protective effect of different form superoxide dismutase on the plasma membrane phospholipid composition of hepatocyte and adipocyte and on the blood lipoprotein composition in hemorrhagic shock in cats, Voprosy meditsinskoi khimii, 1999, vol: 45(5), 389-397.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)