Voprosy meditsinskoi khimii (ISSN 0042-8809)

Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450

   
Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V.
Type: Review
PubMed Id: 10761211
Year: 1999 vol: 45  issue:6  pages: 462-471
Abstract: This article generally reviews new original two-stage approach to aneffictive treatment of solid cancers by killing tumour cells by the activation of aprodrug after the gene encoding for an activating enzyme has been targeted to themalignant cell. The experimental data concerning gene therapy for malignant tumours byusing oxazaphosphorines and cytochrome P450 in a novel combined chemotherapy/cancer genetherapy strategy discussed.
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Reference: Sokolov N.N., Yatzenko A.N., Pokrovskaya M.V., Combined chemotherapy/gene therapy of tumors based on activation of antitumour preparations with genetic constructions containing cytochromes P450, Voprosy meditsinskoi khimii, 1999, vol: 45(6), 462-471.
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