Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the activity of neutral and acidic isoformes of sphingomyelinase in hepatoma-22, regenerating and ischemic liver

   
Alessenko A.V., Zubova E.S., Dudnik L.B., Galperin E.I., Platonova L.V., Shono N.I., Chevokin A.Yu., Dyatlovitskaya E.V.
Type: Experimental study
PubMed Id: 10761212
Year: 1999 vol: 45  issue:6  pages: 472-481
Abstract: Activity of neutral and acidic sphingomyelinases (N- and A-SMases) werestudied in regenerating liver after partial hepatectomy (during 48 hrs after operation),in ischemic liver during 15, 30 min and 1 and 2 hrs ischemia and during followingreperfusion (from 5 min up to 2 hrs), in hepatoma- 22 after 15 days of transplantation andin liver of tumor bearing animals. It was shown that activity of N-SMase is increased inhepatoma-22 and in regenerating liver and it is decreased in ischemic liver.Followingreperfusion of ischemic liver area activity of enzyme was found to have returned tobaseline in dependence on time of ischemia and reperfusion. Activity of A-SMase isdecreased in tumor, is not changed in regenerating liver and increased after long time ofischemia. It was supposed that N-SMase is involved in cell proliferation, but A-SMase isconnected with cell damage.
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Reference: Alessenko A.V., Zubova E.S., Dudnik L.B., Galperin E.I., Platonova L.V., Shono N.I., Chevokin A.Yu., Dyatlovitskaya E.V., Changes in the activity of neutral and acidic isoformes of sphingomyelinase in hepatoma-22, regenerating and ischemic liver, Voprosy meditsinskoi khimii, 1999, vol: 45(6), 472-481.
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