Voprosy meditsinskoi khimii (ISSN 0042-8809)

The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina

   


1. Institute of Nutrition, RAMS, Moscow
2. Moscow State University
PubMed Id: 10802882
Year: 2000 vol: 46  issue:1  pages: 22-27
Abstract: The main events caused by anaphilaxis in selenium haemostasis in rats include significant increase of selenium excretion with urine (6,36± 1,18 nM Se/18 h., n=10, compared with 1,72± 0,38 nM Se/18 h., n=10) and decrease of selenium plasma/selenium erythrocytes ratio from 0,939 to 0,791. Reduced glutathione (G-SH) administration led to 1,5-fold decrease of plasma selenium level and 1,3-fold increase of selenium concentration in intestinal walls of sensitised rats (r=-0,720, P<0,001). Chromatographic separation of plasma proteins showed that intragastric intubation of G-SH to sensibilised rats significantly decreased the protein P content and did not influence the concentration of Se-GSHPx, thus indicating the local selenium acceptor role of G-SH. G-SH administration did not influence the intestinal permeability in sensitised rats while use of complex additive: G-SH and selenium enriched spirulina – normalised the latter parameter and the ratio of protein P/Se-GSHPx in plasma.
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Reference: Golybkina N.A., Mazo V.K., Gmoshinski I.V., Zorin S.N., Tambiev A.H., Kirikova N.N., The selenium haemostasis in rats during anaphylaxis event: effect of reduced glutathione and selenium enriched spirulina, Voprosy meditsinskoi khimii, 2000, vol: 46(1), 22-27.
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