Voprosy meditsinskoi khimii (ISSN 0042-8809)

Vitamin B-6 metabolism in phenylketonuric patients

   


1. Institute of Nutrition at Russian Medical Academy
PubMed Id: 10802890
Year: 2000 vol: 46  issue:1  pages: 81-88
Abstract: Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml shoud be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.
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Reference: Kharitonchik L.A., Kodentsova V.M., Vrzhesinskaya O.A., Denisova S.N., Sprichev V.B., Vitamin B-6 metabolism in phenylketonuric patients, Voprosy meditsinskoi khimii, 2000, vol: 46(1), 81-88.
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