Abstract: Immobilization stress leads to the increase of 99mТс-pyrophosphate accumulation in the heart that points to the cardiomyocyte damage. The stress-reaction was accompanied by a decrease of protein synthesis rate in the heart muscle and immunoreactive insulin level in blood plasma and increase of blood plasma cortisol and aldosteron. Pretreatment with agonists m -opioid receptors DALDA and DAGO (0,1 mg/kg intraperitonealy (i.p.) twice during stress) completely prevented the stress-induction decrease of myocardial protein synthesis rate, heart damage and hormonal imbalance. Cycloheximide administration (0,3 mg/kg i.p.) increased rats myocardial membrane injury during immobilization and reduced cardioprotective effect of DALDA
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Reference: Naryznaya N.V., Maslov L.N., Lishmanov Yu.B., Protein synthesis in heart muscle and the cardioprotective effect of m -opioid receptor ligands at immobilization stress, Voprosy meditsinskoi khimii, 2000, vol: 46(2), 127-154.
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