Voprosy meditsinskoi khimii (ISSN 0042-8809)

Involment of cytochrome P-450 biotransformation system in the mechanisms of toxic effects of acrylamide

   


1. Krasnoyarsk State Agricultural University
PubMed Id: 10885034
Year: 2000 vol: 46  issue:2  pages: 140-148
Abstract: Neuro-, hepato- and geno-toxic effects of the industrial xenobiotic,acrylamide, were studied in intact rats and in rats with induced phenobarbital- and3-methylholanthren- dependent isoforms of cytochrome P-450. The induction of the firstisoform increased neuro- and hepato-toxic effects of acrylamide and decreased the extentof cell genome damage. Activation of the 3-methylholanthren-dependent cytochrome had noinfluence on the toxicity of this xenobiotic. Realisation of toxic effects of acrylamidemay involve a decrease of the carbohydrate energy metalolism, but in the intact organismthese processes precede the induction of the phenobarbital-dependent cytochrome P450.
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Reference: Romanova T.A., Involment of cytochrome P-450 biotransformation system in the mechanisms of toxic effects of acrylamide, Voprosy meditsinskoi khimii, 2000, vol: 46(2), 140-148.
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