Voprosy meditsinskoi khimii (ISSN 0042-8809)

The comparison study of vanadium-compounds with insulin-mimetic properties


1. Institute of Biomedical Chemistry RAMS, Moscow, Russia
PubMed Id: 10885036
Year: 2000 vol: 46  issue:2  pages: 155-161
Abstract: The serum glucose concentration, HbAc1, fructoseamine, theactivity of AST, ALT, amylase, glycogen content and glucokinase activity in rathepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadateand vanadyl sulphate treatment. The improvement of this parameters were demonstrated afteroral orthovanadate and vanadyl sulphate administration. However, insulin-mimeticproperties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was lesstoxic than orthovanadate.
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Reference: Golubev M.A., Gorodetsky V.K., Aniskina A.P., Tochilkin A.I., Belyaeva N.F., The comparison study of vanadium-compounds with insulin-mimetic properties, Voprosy meditsinskoi khimii, 2000, vol: 46(2), 155-161.