Voprosy meditsinskoi khimii (ISSN 0042-8809)

Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances

   


1. Russian Medical Academy for Postgraduate Education, Dept. of Biochem
2. Research Institute for Phthisiopulmonology, Moscow Medical I.Sechenov’s Academy
PubMed Id: 10885039
Year: 2000 vol: 46  issue:2  pages: 176-183
Abstract: 53 patients with lung tuberculosis were divided in 3 groups in accordance with severety of disease. Leukocyte elastase, cationic proteins in neutrophils, activities of a 1-proteinase and a 2-macroglobulin were determined in patients’ plasma. Thromboelastographic, coagulating, fibrinolytic indices, and antithrombin III activity were also determined in 28 patients of all 3 groups. Results demonstrated the high level of leukocyte elastase (6-fold more than normal) in plasma of patients with acute tuberculosis process. This group of patients demonstrated activation of intravascular coagulation proceeded on the background of significant decrease (up to 60%) of AT III activity. Conclusion: Acuity and severety of tuberculosis process in lung may be characterized by high activity of leukocyte elastase. Degranulating activity of neutrophils and releasing of elastase are the reason of AT III deficiency and increasing of intravascular coagulating activity in tuberculosis patients
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Reference: Dotsenko V.L., Spirina A.Ya., Makinsky A.I., Neshkova E.A., Yorshikova Yu.E., Yarovaya G.A., Leukocyte elastase in plasma of patients with pulmonary tuberculosis and its part in blood coagulation disturbances, Voprosy meditsinskoi khimii, 2000, vol: 46(2), 176-183.
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