1. Institute of Agricultural Biotechnology, Moscow, Institute for Viral Preparations, RAMS, Moscow 2. Institute for Viral Preparations, RAMS, Moscow, Institute of Biomedical Chemistry, RAMS
Abstract: Various aspects of use of specific interactions with a participation ofcarbohydrate and oligosaccharide ligands to increase an efficiency of gene transfer intoeukaryotic cells (including in vivo experiments) are considered in details. Data onaddressed gene delivery with applying carbohydrate-containing ligands (such asasialoglycoproteins and galactosides) are discussed in the paper. Results on the usage ofglycoside ligands, containing lactose, mannose, glucose residues, for receptor-mediatedgene transfer, are analysed. Special attention is paid to application of chitosans forfunctional gene transfer into eukaryotic cells, which is considered by authors as a caseof receptor-mediated gene transfer. It is notice that neo-oligosaccharide vectors,recognizing surface lectins, represent very perspective type of gene delivery systems.
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Reference: Krivtsov G.G., Zhdanov R.I., Targeted delivery of functional genes for gene therapy using carbohydrates containing vectors, Voprosy meditsinskoi khimii, 2000, vol: 46(3), 246-255.
18. Wu G.Y., Wu C.H., eds (1991) Liver Diseases, Targeted Diagnosis and Therapy Using Specific Receptors and Ligands, Marcel Dekker, Inc, New York. Scholar google search
19. Chowdhwy N.R., Wu G. Y, Wu C.H. et al (1993) J. Biol. Chem., 268, 11265- 11271. Scholar google search
20. McKee TD., DeRome ME., Wu GY., and Findeis MA. (1994) Bioconjugate Chem., 5, 306-311. Scholar google search
21. Findeis M.A., Merwin J.R., Spitalny G.L and Chiou H.C.(1993) Trends Biotechnol., 11, 202-205. Scholar google search
22. Chiou H.C., Spitalny G.L, Merwin J.R. and Findeis M.A. (1994) In: Gene Therapeutics: Methods and Applications of Direct Gene Transfer (J.A. Wolff,ed.) Birkhauser, Boston, 143-156. Scholar google search
23. Thurner M., Wagner E., Clausen H. et al (1994) Glycobiology, 4, 429-43 5. Scholar google search
24. Kwoh D.Y, Coffin С.С., BrostoffS.W., Carlo DJ. (1999) Biochim. Biophys. Acta, 1444, 171 - 190. Scholar google search
25. Merwin J.R., Noell G.S., Thomas W.L. (1994) Bioconjugate Chem., 5, 612-620. Scholar google search
26. Wadhwa M.S., Knoell D.L, Young A.P., Rice K.G. (1995) Bioconjugate Chem., 6,283-291. Scholar google search
28. Choi Y.H., Liu R, ParkJ.S., Kim S. W. (1998) Bioconjug Chem., 9, 708-718. Scholar google search
29. Erbacher P., Bousser M.-T., Mosigny M, Midoux P., Roche A.C (1996) XVI Jouraees Mediteraneennes du Glucides, la Sorgue Groupe Francais des Glucides, AB22. Scholar google search
30. Erbacher P., Roche A.C, Mosigny M., Midoux P. (1995) Bioconjugate Chem., 6, 401-410. Scholar google search
31. Kren В. Т., Bandyopadhyay P, Steer C. (1998) Nature Medicine, 4, 285-290/ Scholar google search
32. Евстигнеева Р.П., Себякин Ю.Л., E.B. Калинина, Казакова Е.В. (1992) Доклады Академии наук, 325, 959-963. Scholar google search
33. Diebold S.S., Kursa M., Wagner K, Cotten M., Zenke M. (1999) J Biol Chem., 274, 19087-19094. Scholar google search
34. Diebold S.S., Lehrmann H., Kursa M., Wagner E., Cotten M., Zenke M. (1999) Hum. Gene Ther., 10, 775-786. Scholar google search
35. Kollen W.J., Midoux P., Erbacher P. et al (1996) Hum. Gene Ther , 7, 1577-1586. Scholar google search
36. Zhdanov R.I., Serebrennikova G.A., Borisenko A.S., et al (2000) FEBS Lett, (submitted). Scholar google search
37. Stewart A.J, Pichon C, Meunier L. et al (1996) Mol. Pharmacol., 50, 1487-1494. Scholar google search
38. Erbacher P., Zou S., Bettinger T.et al (1998) Pharmaceutical Research., 15, 1332-1339. Scholar google search
39. Venkatesh S., Smith J (1998) Biotechnol Appl. Biochem., 27, 265-267 Scholar google search
40. Venkatesh S., Smith J (1997) Pharmaceut Dev Tech., 2, 417- 418. Scholar google search
41. MacLaughlin F.C., Mumper R.J., Wang J. et al (1998) J. Controlled Release, 56, 259-272. Scholar google search
42. Lee K.Y., Kwon.I.C, Kim Y.-H. et al (1998) J. Controlled Release, 51, 213-220. Scholar google search
43. Leong K. W., Mao H.-Q., Truong-Le V.L. et al (1998) J. Controlled Release,. 53, 183-193. Scholar google search
44. Mellow Т.Е., Halberg D., Drickamer К (1988) J. Biol. Chem., 263, 5468- 5473. Scholar google search
45. Bellemin-Magninot P. et al (1992) Int. J. Biochem., 24, 827-830 Scholar google search
46. Yoneda Y., Imamoto-Sonobe N., Yamaizumi M., Uchida T. (1987) Exp. Cell Res., 173, 586-595 Scholar google search
47. Finlay D.R, Newmeyer D.D., Price T.M., and Forbes DJ. (1987) J Cell Biol., 104, 189-200. Scholar google search
58. Gabius S., Kayser K., Bovin N. V. et al(1996) Eur. J. Pharmaceut. Biopharmaceut., 42, 250-261. Scholar google search
59. Zhdanov R.I., Podobed O. V., Bovin N. V. et al (1997) Abstract book of Keystone Symposium "Molecular and Cellular Biology in Gene Therapy", Snowbird, U.S.A., 107, 10. Scholar google search
60. Zhdanov R.I., Bovin N. V., Sergeeva N.S. (1998) Abstract book of 6th Symposium on Gene Therapy "Towards Gerje Therapeutics", MDC, Berlin, Germany,'May 4-6, 1998, p. 103. Scholar google search
