Voprosy meditsinskoi khimii (ISSN 0042-8809)

Targeted delivery of functional genes for gene therapy using carbohydrates containing vectors

   


1. Institute of Agricultural Biotechnology, Moscow, Institute for Viral Preparations, RAMS, Moscow
2. Institute for Viral Preparations, RAMS, Moscow, Institute of Biomedical Chemistry, RAMS
PubMed Id: 11033884
Year: 2000 vol: 46  issue:3  pages: 246-255
Abstract: Various aspects of use of specific interactions with a participation ofcarbohydrate and oligosaccharide ligands to increase an efficiency of gene transfer intoeukaryotic cells (including in vivo experiments) are considered in details. Data onaddressed gene delivery with applying carbohydrate-containing ligands (such asasialoglycoproteins and galactosides) are discussed in the paper. Results on the usage ofglycoside ligands, containing lactose, mannose, glucose residues, for receptor-mediatedgene transfer, are analysed. Special attention is paid to application of chitosans forfunctional gene transfer into eukaryotic cells, which is considered by authors as a caseof receptor-mediated gene transfer. It is notice that neo-oligosaccharide vectors,recognizing surface lectins, represent very perspective type of gene delivery systems.
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Reference: Krivtsov G.G., Zhdanov R.I., Targeted delivery of functional genes for gene therapy using carbohydrates containing vectors, Voprosy meditsinskoi khimii, 2000, vol: 46(3), 246-255.
References
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