1. Institute of Agricultural Biotechnology, Moscow, Institute for Viral Preparations, RAMS, Moscow 2. Institute for Viral Preparations, RAMS, Moscow, Institute of Biomedical Chemistry, RAMS
Abstract: Various aspects of use of specific interactions with a participation ofcarbohydrate and oligosaccharide ligands to increase an efficiency of gene transfer intoeukaryotic cells (including in vivo experiments) are considered in details. Data onaddressed gene delivery with applying carbohydrate-containing ligands (such asasialoglycoproteins and galactosides) are discussed in the paper. Results on the usage ofglycoside ligands, containing lactose, mannose, glucose residues, for receptor-mediatedgene transfer, are analysed. Special attention is paid to application of chitosans forfunctional gene transfer into eukaryotic cells, which is considered by authors as a caseof receptor-mediated gene transfer. It is notice that neo-oligosaccharide vectors,recognizing surface lectins, represent very perspective type of gene delivery systems.
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Reference: Krivtsov G.G., Zhdanov R.I., Targeted delivery of functional genes for gene therapy using carbohydrates containing vectors, Voprosy meditsinskoi khimii, 2000, vol: 46(3), 246-255.
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