Voprosy meditsinskoi khimii (ISSN 0042-8809)

Listeria monocytogenes: nasty pathogen but useful tool for vaccine development


1. Stanford University, B259 Campus Dr., CA 94305, USA
2. Belozerskiy Institute of Lomonosov Moscow State University, 119899 Moscow
3. Institute of Transplantation and Artificial Organs, 123182 Moscow
PubMed Id: 11033885
Year: 2000 vol: 46  issue:3  pages: 256-263
Abstract: Listeria monocytogenes (LM) has become a major pathogen of human foodborne illnesseseliciting meningitis, peritonitis, and abortions with a mortality rate of about 30%.During the course of the disease, LM infects a variety of tissues and cell types due toits capacity to induce its own phagocytosis even into non-phagocytic cells. For over 35years LM continues to serve as a model to define general paradigms of immunology In thisreview we focus on the clinical characteristics of listeriosis, on the risk factorsinvolved in the pathogenesis, and discuss the currently accepted approaches to prophylaxisand treatment. We report on novel strategies in vaccine development based on theLM-dependent delivering machinery for immune recognition and induction of immunologicalmemory against desired antigens.
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Reference: Tkachuk M.V., Yarovinsky F.O., Tonevitsky A.G., Listeria monocytogenes: nasty pathogen but useful tool for vaccine development, Voprosy meditsinskoi khimii, 2000, vol: 46(3), 256-263.