Voprosy meditsinskoi khimii (ISSN 0042-8809)

The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells

   


1. Institute of Biomedical Chemistry RAMS
PubMed Id: 11075420
Year: 2000 vol: 46  issue:4  pages: 377-383
Abstract: The synthesizedpeptides represent the functionally important site for binding to insulin receptor. Aminoacids of peptide I correlate with B-chain of insulin at the position B19-B26 and A-chainat the position A20-A21. amino acids of peptide II correlate with B-chain of insulin atposition B23-B26 and A-chain at the position A20-A21. It was shown, that the thesepeptides increased liposomal binding followed by receptor-mediated endocytosis by cellsPC12.
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Reference: Maslov D.L., Prozorovskiy V.N., The study of the interaction liposomes coated by synthetic fragments of insulin with PC12 cells, Voprosy meditsinskoi khimii, 2000, vol: 46(4), 377-383.
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