1. University of Arkansas for Medical Sciences 2. Burdenko Research Institute for Neurosurgery RAMS 3. Orechovich Institute of Biomedical Chemistry RAMS
Abstract: Spinal trauma is a serious problem of modern medicine. The morphological studiesillustrate the presence of two alternative pathways of cell destruction in the injuredspinal cord: immediate necrotic damage and delayed apoptotic destruction of cells. Theapoptosis continues for about 14 days after trauma, and it involves both neurons and gliaon a significant distance from the traumatic zone. In this review, the basic stages ofapoptosis in spinal cord, biochemical regulation of this process, and methods for itsdetection are considered. The fact, that apoptosis is a normal cell death process, andthat it has reversible stages allows to consider a possibility of pharmacologicalcorrection of apoptosis. The special attention is paid to anti-apoptotic therapy with theuse of antisense oligodeoxynucleotides and to the perspectives of gene therapy.
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Reference: Basnakian A.G., Baskov A.V., Sokolov N.N., Borshenko I.A., Apoptosis after traumatic spinal cort injuri: prospects of the pharmacological correction reveiw, Voprosy meditsinskoi khimii, 2000, vol: 46(5), 431-443.
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