Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibitors of proteolytic enzymes in the therapy of diabetes

   


1. Topchiev Institute of Petrochemical synthesis, Russian Academy of Sciences
PubMed Id: 11385995
Year: 2001 vol: 47  issue:1  pages: 132-154
Abstract: A newapproach to overcome the degradation of insulin by proteolytic enzymes and its targetingto the blood through the digestive apparatus was developed. The approach is based on theimmobilization of insulin into the polymeric hydrogel which is modified by ovomucoid -glycoprotein, inhibitor of proteolytic enzymes. Oral administration of this system torabbits and rats, (in contrast to the hydrogels modified by proteolytic enzymes inhibitorswithout polysaccharide part), statistically significantly lowered blood glucose level.
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Reference: Valuev I.L., Sytov G.A., Valuev L.I., Valueva T.A., Ul'yanova M.V., Plate N.A., Inhibitors of proteolytic enzymes in the therapy of diabetes, Voprosy meditsinskoi khimii, 2001, vol: 47(1), 132-154.
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