Voprosy meditsinskoi khimii (ISSN 0042-8809)

Angiotensin-converting enzyme, its physiological role


1. Orekhovich Institute of Biomedical Chemistry, RAMS
Type: Review
PubMed Id: 11385998
Year: 2001 vol: 47  issue:1  pages: 43-54
Abstract: angiotensin-convertingenzyme (ACE, peptidyl dipeptidase A) is well known as a key enzyme involved in regulationof blood pressure. Regulation of blood pressure is the main but not the only ACE function.This enzyme is also involved in the regulation of a rangeof other physiological processes including control of cellsproliferation. Particular role of the enzymein a given process is determined by itslocalization and its action on regulatory peptides. Structural peculiarities ofangiotensin-converting enzyme and its gene polymorphism related to its physiologicalfunction are discussed. ACE molecule consists of two largehomologous domains (N- and C-domains), differingin their catalytical properties. These differences are suggested to be physiologicaly impotant. Endogenous substratesspecific for each of these domains and natural active single-domain ACE forms wererevealed. An association between the ACE gene polymorphism and plasma ACE levels, as well as with an increased risk ofvarious cardiovascular and renal diseases was observed.
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Reference: Elisseeva Yu.E., Angiotensin-converting enzyme, its physiological role, Voprosy meditsinskoi khimii, 2001, vol: 47(1), 43-54.