Voprosy meditsinskoi khimii (ISSN 0042-8809)

Affinity chromatograpy of DNA-protein complexes


1. St.Petersburg Institute of Bioregulation and Gerontology, North-Western Department of the Russian Academy of Medical Sciences
2. Institute of Macromolecular Compounds, Russian Academy of Sciences
PubMed Id: 11450441
Year: 2001 vol: 47  issue:2  pages: 209-216
Abstract: Affinity sorbentcontaining cellular membranes of the cerebral cortex was obtained by means of an inclusioninto porous matrix of polyacrylonitryl. Sorption of model and natural nucleoproteincomplexes on the obtained sorbent was studied by the method of affinity chromatography.Distribution coefficients were determined. naturalnucleoprotein complexes isolated from brain possess a greater selectivity of binding tothe cellular membranes of the cerebral cortex than that from liver.
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Reference: Riadnova I.Yu., Chernova I.A., Shataeva L.K., Khavinson V.Kh., Affinity chromatograpy of DNA-protein complexes, Voprosy meditsinskoi khimii, 2001, vol: 47(2), 209-216.