Voprosy meditsinskoi khimii (ISSN 0042-8809)

Liver mitochondria in realisation of antigenic strain in rats


1. Institute of theoretical and experimental biophysics of Russian Academy of Sciences
2. Surgery institute of Armenian Ministry of Health, Republic of Armenia.
PubMed Id: 11450442
Year: 2001 vol: 47  issue:2  pages: 217-226
Abstract: The penomenon ofreciprocal regulation of succinate dehidrogenase activity in rat liver mitochondria waselicited in antigenic strain induced by the administration of activated lymphocytes fromanimals with allotransplated heart. Two coupled but oppositechanges (simultaneous activation and inhibition) in succinate depended ATP synthesis andcalcium transport occur. The inhibition was correlated with the activation of syntheticprocesses in hepatocytes. Similar changes were provoked by epinephrine (eitheradministered i.p. or relased endogenously under immobilization stress and in myocardiuminfarction) as well as in patients with stomach tumor. The physiological significance ofthe reciprocal regulation of succinate dehydrogenase is discussed.
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Reference: Saakyan I.R., Karapetyan T.D., Saakyan H.G., Liver mitochondria in realisation of antigenic strain in rats, Voprosy meditsinskoi khimii, 2001, vol: 47(2), 217-226.