Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin


1. Department of Biophysic, Russian State Medical University
2. State Research Center for Laser Medicine Health Ministry
3. Moscow Medico-Dental University
4. TOO "Science Center"
PubMed Id: 11558311
Year: 2001 vol: 47  issue:3  pages: 288-300
Abstract: Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin - hydrogen peroxide - luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride - luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds
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Reference: Klebanov G.I., Lyubitsky O.B., Vasiljeva O.V., Klimov Yu.A., Penzulaeva O.B., Teplyashin A.S., Tolstyh M.P., Promorenko V.K., Vladimirov Yu.A., Antioxidant properties of analogues of 3-oxypyridine: mexidol, emoxipin, proxipin, Voprosy meditsinskoi khimii, 2001, vol: 47(3), 288-300.