Voprosy meditsinskoi khimii (ISSN 0042-8809)

Insulin degradation in hepatocytes and erythrocytes from normal and experimental diabetic rats

   


1. Department of Biochemistry, Saint-Petersburg State Chemical Pharmaceutical Academy
PubMed Id: 11558315
Year: 2001 vol: 47  issue:3  pages: 329-337
Abstract: Insulin metabolism in erythrocytes and hepatocytes of normal andexperimental diabetic rats was studied. Insulin-degrading complex of erythrocytes andhepatocytes was investigated at low insulin concentration in blood. Kinetic parameters ofinsulinase depend on insulin concentration in blood have shown. Thermo-acid resistantnon-competitive endogenous inhibitors were purified from erythrocytes and hepatocytes.Increase of endogenous inhibitors influence insulin-degrading enzyme in diabetes.Synthesis of insulin-degrading enzyme in hepatocytes of diabetic rats was reduced. Theseresults suggest that insulin-degrading activity in erythrocytes and hepatocytes isregulated by endogenous inhibitors, by synthesis of insulinase. This change of bloodinsulin concentration influences practically all the components of insulin-degradingcomplex.
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Reference: Nikolaev S.L., Strelkova M.A., Komov V.P., Insulin degradation in hepatocytes and erythrocytes from normal and experimental diabetic rats, Voprosy meditsinskoi khimii, 2001, vol: 47(3), 329-337.
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