Voprosy meditsinskoi khimii (ISSN 0042-8809)

The involvement of antioxidant enzymes in the cardioprotective effect of d-opioids during oxidative stress

   


1. Institute of Cardiology, Tomsk, Russia
2. 'NitroMed', Bedford, Massachusetts, USA
PubMed Id: 11558316
Year: 2001 vol: 47  issue:3  pages: 338-345
Abstract: Intravenous administration of peptide d2-opioid receptor agonists increased cardiac sarcolemma resistance to subsequent oxidative stress in the isolated perfused rat heart in vitro. d-Opioid receptor stimulation prevented oxidative stress-induced accumulation of lipid peroxides in myocardium and inhibition of superoxide dismutase. The cardioprotective and 'antioxidant' effects of d-agonists were completely abolished by in vivo pretreatment with the b-receptor antagonist ICI 174,864. µ-Opioid receptor activation in vivo did not protect the isolated myоcardium from cardiotoxic action of activated oxygen species
Download PDF:
Reference: Rebrova T.Yu., Maslov L.N., Tam S.W., The involvement of antioxidant enzymes in the cardioprotective effect of d-opioids during oxidative stress , Voprosy meditsinskoi khimii, 2001, vol: 47(3), 338-345.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)