Voprosy meditsinskoi khimii (ISSN 0042-8809)

Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis

   


1. Molecular Pathology Group, Research Institute of Traumatology and Orthopedics
2. Department of Biochemistry, Schooll of Medicine, Russian Peoples' Friendship University
PubMed Id: 11558317
Year: 2001 vol: 47  issue:3  pages: 346-352
Abstract: Possible molecular mechanisms underlying changes in catalytical properties of alcoholdehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. Thedevelopment of toxic hepatitis is accomanied by significant changes in the activity of ADHand LDH assayed in subcellular fractions and kinetic characteristics of these enzymes.Thiscan result in an increase cellular level of acetylaldehyde and lactate which promotes thedevelopment of liver cirrosis.
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Reference: Zimin Yu.V., Syatkin S.P., Berezov T.T., Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis, Voprosy meditsinskoi khimii, 2001, vol: 47(3), 346-352.
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