Voprosy meditsinskoi khimii (ISSN 0042-8809)

Computer searching of new targets for antimicrobial drugs based on comparative analysis of genomes

   


1. Orekhovich institute of Biomedical Chemistry, RAMS
PubMed Id: 11558318
Year: 2001 vol: 47  issue:3  pages: 353-367
Abstract: The progress in genome research allows to use genomic databases for drug discovery. Themajor interest consists in their usage for searching of new molecular targets for newdrugs. It is especially important in the area of new antimicrobial drugs creation. Inrecent years, the applicability of genome analysis for solution of this problem was shownby different authors. We propose an approach for searching new targets for antimicrobialdrugs based upon comparative analysis of genomes and samples from molecular databases. Foreach protein encoded by the target microorganism genome the conformance to a number ofmedico-biological and technological requirements was tested. The obtained evaluations wereused for selection of potential targets. The approach was implemented in the originalsoftware GenMesh. It was successfully tested with known targets of drugs againsttuberculosis when correct valuations were obtained. The attempt of new targets selectionfor design of new drugs against tuberculosis was done with reliable results.
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Reference: Dubanov A. V., Ivanov A. S., Archakov A. I., Computer searching of new targets for antimicrobial drugs based on comparative analysis of genomes , Voprosy meditsinskoi khimii, 2001, vol: 47(3), 353-367.
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