Voprosy meditsinskoi khimii (ISSN 0042-8809)

Modulation of hepatocyte prolifaration of ischemic rat liver bytauroursodeoxycholic acid

   


1. Vitebsk Medical University
PubMed Id: 11693028
Year: 2001 vol: 47  issue:4  pages: 405-410
Abstract: The influence of the tauroursodeoxycholic acid (TUDCA) on hepatocyte proliferationafter 180-minute ischemia of rat liver was investigated. TUDCA in a dose of 200 mg/kg didnot change hepatocyte proliferation in the liver of intact rats and had no cytotoxiceffect. The preliminary introduction of TUDCA accelerated regenerative processes in theliver in the postischemic period possibly due to synchronization of hepatocyte division.The membrane stabilizing effect of TUDCA manifested in reduction of the liver enzymeactivity in blood serum was found.
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Reference: Danchenko E.O., Modulation of hepatocyte prolifaration of ischemic rat liver bytauroursodeoxycholic acid, Voprosy meditsinskoi khimii, 2001, vol: 47(4), 405-410.
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