Voprosy meditsinskoi khimii (ISSN 0042-8809)

ACE-depended and sympathetic components of arterial blood pressure regulation inpatients with essential hypertension

   


1. National Research Centre for Preventive Medicine
2. Orekhovich Institute of Biomedical Chemistry RAMS
PubMed Id: 11693029
Year: 2001 vol: 47  issue:4  pages: 411-418
Abstract: The development of arterial hypertension is accompamed by impairment of the normalratio of the "ACE-depending" and of the sympathetic nervous system, correlateswith the action on the main pharmacological "targets": I-1-imidazoline receptors(moxonidine) or the ACE activity (enalapril). The aim of the present investigation was todetermine the hypotensive and metabolic effects of moxonidine and enalapril depending onthe basal ACE activity in patients with arterial hypertension, complicated with themetabolic syndrome. Effectiveness of moxonidine and enalapril administration (diring 24weeks) depended on the basal ACE activity in the hypertensive patients: (a) in the groupof patients with low basal ACE activity moxonidine very effectively decreased systolic anddyastolic blood pressure, compared with the group of patients with high basal ACEactivity; (b) influence of enalapril on the level of arterial blood pressure was morepronounced with high basal ACE activity. In conclusion: choosing a hypotensive treatmentfor patients with the metabolic syndrome, it is advisable to take into account the basalACE activity levels.
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Reference: Aparina T.V., Gomazkov O.A., Dilakyan E.A., Britov A.N., ACE-depended and sympathetic components of arterial blood pressure regulation inpatients with essential hypertension, Voprosy meditsinskoi khimii, 2001, vol: 47(4), 411-418.
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