Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of mannose derivatives on rat and mouse selectin-dependent inflammation


1. Orehovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
PubMed Id: 11766259
Year: 2001 vol: 47  issue:5  pages: 491-497
Abstract: The inhibitory effect of mannose-containing oligosaccharides on model carbohydrateligand interaction with E-, P- and L-selectins in vitro, as well as on theability of these compounds to block the leukocyte extravasation in rat and mouseperitonitis in vivo was studied. The monomeric and polymeric compounds,4-nitrophenylthiomannoside, phenylmannoside, conjugated with polyacrylic acid, and a-mannose,conjugated with polyacrylamide, inhibited the binding of the model ligand to P- andL-selectins (but not to E-selectin). Intravenous injection of these compounds was found tocause a dose-dependent reduction of neutrophil accumulation in rat peritoneum. Thepolysaccharide mannan was inactive in both types of experiments. The conjugate ofphenylmannoside with polyacrylic acid was the most effective blocker as in vitroexperiments, as well as in vivo. The inhibitory effect of subcutaneous injectionof 4-nitrophenylthiomannoside on mouse peritonitis was demonstrated.
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Reference: Ushakova N.A., Preobrazhenskaya M.E., Nifantev N.E., Voznyi Ya.V., Pochechueva T.V., Bovin N.V., Effect of mannose derivatives on rat and mouse selectin-dependent inflammation , Voprosy meditsinskoi khimii, 2001, vol: 47(5), 491-497.