Voprosy meditsinskoi khimii (ISSN 0042-8809)

The lipids of the bone tissue bodies of the vertebrae in experimental scoliosis


1. The Russian Turner Research Children Orthopaedic Institute, The Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS
PubMed Id: 11766262
Year: 2001 vol: 47  issue:5  pages: 511-516
Abstract: The content of total lipids, triglycerides, cholesterol and phospholipids in the bonetissue of the bodies of the thoracic vertebrae was investigated in 4.5-, 7- and 12 monthold rabbity. The development of scoliosis in two month old animals was induced by theone-sided blockade of the afferent links of the innervation in thoracic region at theextent of four segments (TH6-9). In: experimental scoliosis there were importantalternations in the content of the total lipids comparing with the control which areobserved only on the level of the primary and of the anterior compensatory curves in 12months old animals. The content of triglycerides changed even at early stages of thedevelopment of scoliosis. A decrease of triglycerides content was observed at the level ofthe primary curve in rabbits of all ages with experimental scoliosis. Probably it is dueto the alteration of neurotrophic processes in the bone tissue. There were similarage-related changes of triglyceride content in both groups of animals. Phospholipids haveabsolutely another than triglycerides dynamics of the content changes during the scoliosisdevelopment. Time-course of phospholipid changes in scoliosis differred from thet oftriglycerides. In older rabbits with experimental scoliosis the cholesterol content in thebone tissue of vertebral bodies was reduced by 1.5-2 times while in normal animals itremained almost unhanged. The most substantial changes in cholesterol content of thevertebral bone tissue in rabbbits with the experimental scoliosis occur in early age (4.5months) on the level of the primary curve and the posterior compensatory curve. This maybe considered as one of the biochemical indicators of the progressing scoliosis.
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Reference: Davidyan T. G., Gayvoronsky G. I., Chebotaryova M. A., The lipids of the bone tissue bodies of the vertebrae in experimental scoliosis, Voprosy meditsinskoi khimii, 2001, vol: 47(5), 511-516.