Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of reactive oxygen species as signal molecules in tissue metabolism under conditions of oxidative stress

   


1. Psychoneurological Bekhterev Institute Russia
PubMed Id: 11925746
Year: 2001 vol: 47  issue:6  pages: 561-581
Abstract: This review deals with literature data on the functioning of the reactive oxygenspecies (ROS) as second messengers. ROS induce various biological processes such asstimulation of protein phosphorylation, Ca2+- signaling, phospholipid hydrolysis andtranscription factor activation. Physiological significance of the role of biologicaloxidants in the regulation of signal transduction and the mechanisms of the adaptation oforganism to extremal conditions are discussed. Oxidative stress is a common step for thedevelopment of many diseases characterized by the intensive ROS generation.
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Reference: Dubinina E.E., The role of reactive oxygen species as signal molecules in tissue metabolism under conditions of oxidative stress, Voprosy meditsinskoi khimii, 2001, vol: 47(6), 561-581.
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