Voprosy meditsinskoi khimii (ISSN 0042-8809)

Blood fatty acid transporters in acute pancreatitis


1. Russia State Medical University
2. Moscow Research Institute for Physical Chemical Medicine
PubMed Id: 11925755
Year: 2001 vol: 47  issue:6  pages: 633-643
Abstract: A relationship between of acute pancreatitis severity and concentrations of blood transporters of nonesterified fatty acids (albumin) and esterified fatty acids (lipoproteins) was studied. In necrotizing pancreatitis, there was a positive correlation between decrease of albumin and lipoprotein concentrations in serum, but no correlation was in edematous pancreatitis. High levelы of serum albumin (> 32 g/L) and lipoproteins (cholesterol+triglycerides, CH+TG, > 260 mg/dL) had good prognostic valu in terms of favourable development of this disease, whereas lower concentrations indicated unfavourable prognosis. Both albumin and lipoproteins appeared in the peritoneal exsudate where they represented 73 and 53% of the serum concentrations, respectively. Albumin efflux from blood to the exsudate correlated with lipoprotein efflux (r = 0.7) in necrotizing pancreatitis. The latter suggests that proteins penetrated together the tissue barrier blood/peritoneal space. The less albumin and lipoprotein concentrations in serum, the more they are in the exsudate (r = -0.57 and -0.47, respectively); probably, their concentration decrease in blood is due to to their efflux into the exsudate.
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Reference: Rodoman G.V., Shalaeva T.I., Dobretsov G.E., Blood fatty acid transporters in acute pancreatitis , Voprosy meditsinskoi khimii, 2001, vol: 47(6), 633-643.