Voprosy meditsinskoi khimii (ISSN 0042-8809)

The neurochemical basis for ultra rapid opioid detoxification


1. North-West Regional Therapeutic and Diagnostic Center "Behterev"
2. West Virginia University
PubMed Id: 12189623
Year: 2002 vol: 48  issue:2  pages: 154-173
Abstract: Ultra rapid opioid detoxification(UROD) is a new technique with the use of m-opioid receptor antagonists to precipitatewithdrawal. The scientific literature on UROD techniques in opiate addicts are reviewed,but little has been published on its neurochemical aspects. It is discussed that exposureto naloxone ore naltrexone during UROD is associated with development of increasing inopioidergic neurotransmission. On the other hand, ultra rapid opioid detoxification can beaccompanied by normalization of joined brain neurotransmitter systems: noradrenergic,serotoninergic, GABAergic, cholinergic and glutamatergic neurotransmission systems. Theneurochemical aspects of the new method detoxification are discussed.
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Reference: Golovko A.I., Leontieva L.V., Golovko S.I., Zefirov S.J., Konoplin D.A., Romanenko O.I., The neurochemical basis for ultra rapid opioid detoxification, Voprosy meditsinskoi khimii, 2002, vol: 48(2), 154-173.