Voprosy meditsinskoi khimii (ISSN 0042-8809)

Peculiarities of toxic effect of somecontaminators of water medium on structural functional parameters of hepatocytes

   


1. Tashkent State Second Medical Institute, Uzbekistan
PubMed Id: 12189624
Year: 2002 vol: 48  issue:2  pages: 174-179
Abstract: A prolonged intragastralintoxication of male and female rats by low doses of fluorine, zinc, chromium, arsenite,and combination of these compounds lead to developing cytolysis and hepatic-cellularinsufficiency. These changes are more pronounced in female rats especially if chromium,arsenite and a combination of toxicants were used. They lead to developing hyper lipidperoxidation in male rats the most expressed by intoxication with arsenite and combinedeffect. Unlike to male rats LPO intensity in female rats was more pronounced and fixed byeffect of all preparations. SOD activation was revealed to be in male rats by effect ofchromium and especially zinc, in female rats by effect of fluorine and zinc. A distinctive inhibition of SOD activity determined to be by usingarsenite and combination of toxicants. Activation of catalase especially in male rats wasalso revealed. An activation ofmembrane-destructive processes in the liver of experimental animals results in reducingpharmaco-metabolizing function of this organ.
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Reference: Karimov Kh.Ya., Inoyatova F.H., Inoyatov F.Sh., Peculiarities of toxic effect of somecontaminators of water medium on structural functional parameters of hepatocytes, Voprosy meditsinskoi khimii, 2002, vol: 48(2), 174-179.
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