Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effects of stimulation and inhibition of themononuclear phagocyte system function on hypercholesterolemia development in rats

   


1. Institute of Internal Medicine, Siberian Division of the Russian Academy of Medical Sciences
2. Scientific Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences
PubMed Id: 12189625
Year: 2002 vol: 48  issue:2  pages: 180-188
Abstract: In this study we investigated the effects of zymosan and prodigiozan, the macrophage stimulators, and GdCl3, a macrophage inhibitor, on blood lipoprotein composition, activities of liver cholesteryl ester (CE) metabolising enzymes, incorporation of [14C]cholesterol (C) into bile acids and accumulation and synthesis of CE in peritoneal macrophages (PM) of rats fed with C-enriched diet during 7 days. The increase in phagocyte cell in liver and in blood colony-stimulating activity level after previously intravenous injection of zymosan and prodigiozan was accompanied by reduced C content in blood low density and very low density lipoproteins (LDL and VLDL), increase of liver lysosomal CE hydrolase activity (without change of acyl-CoA:C acyltransferase and cytoplasmatic CE hydrolase activities) and incorporation of labeled C into bile acids and decrease of CE formation and accumulation in PM in rats with hypercholesterolemia. In contrast, reduction of phagocyte population in liver by intravenous injection of GdCl3 was accompanied by enhancement of C and CE level in blood LDL and VLDL and decrease of lysosomal CE hydrolase activity and incorporation of C into bile acids in liver of C-feeding rats. The data obtained suggest that stimulation of the mononuclear phagocyte system may lead to a decrease of plasma C via activation of LDL and VLDL catabolism and induction of bile acid synthesis in liver
Download PDF:
Reference: Kuznetzov P.O., Safina A.F., Schwartz Y.Sh., Tsyrendorjiev D.D., Zubakhin A.A., Dushkin M.I., Effects of stimulation and inhibition of themononuclear phagocyte system function on hypercholesterolemia development in rats, Voprosy meditsinskoi khimii, 2002, vol: 48(2), 180-188.
References
 2002(Vol:48)
 2001(Vol:47)
 2000(Vol:46)
 1999(Vol:45)
 1998(Vol:44)
 1997(Vol:43)
 1996(Vol:42)