Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases

   


1. CRRET Laboratory, CNRS FRE2412
2. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
PubMed Id: 12189628
Year: 2002 vol: 48  issue:2  pages: 201-203
Abstract: There is increasing evidence, that oxidized indoles, isatin, 5-hydroxyoxindole,2-oxindole, play important regulatory functions in the brain. Isatin and 5-hydroxyoxindoleshare some common regulatory properties in cell cultures (Cane et al., 2000, BBRC,276,379), however, their effects on brain mitochondrial monoamine oxidases, a potential targetfor their action, have not been compared yet. Isatin acted as a rather selective monoamineoxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase Ainhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue ofisatin.
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Reference: Crumeyrolle M., Tournaire M.C., Cane A., Medvedev A.E., The effect of some oxidized indoles on the activity of rat brain mitochondrialmonoamine oxidases, Voprosy meditsinskoi khimii, 2002, vol: 48(2), 201-203.
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