Voprosy meditsinskoi khimii (ISSN 0042-8809)

Impairment of platelet lipid composition during the development of heavy formsof angina pectoris

   


1. Тashkent Medical Institute of Postgraduate Training
PubMed Id: 12189630
Year: 2002 vol: 48  issue:2  pages: 215-218
Abstract: Investigation was performed on 54 patients with angina pectoris. The patients weredivided into three groups. Group 1 included patients with angina pectoris of functional classes I-II, group 2 consisted of thepatients with angina pectoris classes III-IV, and group 3 - unstable angina pectoris. Allthe patients underwent investigation of content and ratio of some fraction of thephospholipids and cholesterol metabolites in the thrombocyte membranes. Results ofinvestigation showed damage of phospholipid metabolism of the thrombocyte membranes. Thisis manifested by increased in content of lysophosphatidylcholine (LPCh),phosphatidylserine (PS) and phosphatidyletanolamine (PEA), decreased levels ofsphingomyelin (SM) and phosphatidylcholine (PCh). The angina pectoris of effort of thefunctional classes III-IV and unstable angina pectoris were manifested by severe damage oflipid metabolism in the thrombocyte membranes.
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Reference: Tulabaeva G.M., Akhmedova N.A., Impairment of platelet lipid composition during the development of heavy formsof angina pectoris, Voprosy meditsinskoi khimii, 2002, vol: 48(2), 215-218.
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