Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection

   


1. Palladin Institute of Biochemistry, NAS of Ukraine
PubMed Id: 12243084
Year: 2002 vol: 48  issue:3  pages: 264-270
Abstract: The effect of administration of 3-acetylpyridine (antivitamin B3), on rat brain serotoninergic and NAD receptor systems was investigated. The injection of 3-acetylpyridine to rats caused a decrease of NAD and serotonin content in the brain and changes in [U-14C]NAD binding to synaptic membranes, serotonin uptake by nerve endings, as well as sensitivity of this process to NAD (10-5 M). Pretreatment of animals with nicotinamide restored modulating effect of NAD
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Reference: Kuchmerovskaya T.M., The effect of NAD on brain serotoninergictransmission of rats under 3-acetylpyridine injection, Voprosy meditsinskoi khimii, 2002, vol: 48(3), 264-270.
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