Voprosy meditsinskoi khimii (ISSN 0042-8809)

Current trendsin the pharmacotherapy of type 2 diabetesmellitus


1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
2. Moscow Medical Sechenov’s Academy
3. Russian Medical Academy of Postgraduate Education. The department 'General Pathology and Pathophysiology'
Type: Review
PubMed Id: 12506608
Year: 2002 vol: 48  issue:4  pages: 337-352
Abstract: The pharmacological approaches to the treatment of type 2 diabetes mellitus werereviewed. Special attention was paid to the new therapeutic agents that are able todecrease plasma glucose levels. The possible mechanisms of the hypoglycemic effects arediscussed. Briefly, repaginide, nateglinede and a-glucosidaseinhibitors prevent postprandial hypoclycemia while thiazaolidinediones improve thesensitivity to insulin and vanadium compounds act as an insulin action enhancer.
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Reference: Kovelman I.R., Tochilkin A.I., Belayeva N.F., Gorodetskii V.K., Knyazhev V.A., Tkachenko C.B., Semenov L.L., Semenova N.V., Current trendsin the pharmacotherapy of type 2 diabetesmellitus, Voprosy meditsinskoi khimii, 2002, vol: 48(4), 337-352.