Voprosy meditsinskoi khimii (ISSN 0042-8809)

DNA oxidation by free radicals and its biomarker oxidizedguanosine (8-oxodg)

   


1. Pharmacological Research Institute and Department of Pharmacology of Volgograd Medical Academy
Type: Review
PubMed Id: 12498082
Year: 2002 vol: 48  issue:5  pages: 419-431
Abstract: Endogenous free radicals, inparticular, reactive species of oxygen, nitrogen, chlorine cause DNA oxidation which ispotentiated by exogenous prooxidant factors. The free radicals cause various DNA damages.This review highlights one of them, oxidative modification of guanosine, and also modernmethods of the estimation of oxidized guanosine (8-oxodG) content. The numerous data on aninduction of 8-oxodG in DNA by exogenous genotoxicants in vitro and in vivo are presented.8-oxodG is used as a biomarker of DNA oxidation, accompanying some human diseases.
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Reference: Zinovjeva V.N., Ostrovsky O.V., DNA oxidation by free radicals and its biomarker oxidizedguanosine (8-oxodg), Voprosy meditsinskoi khimii, 2002, vol: 48(5), 419-431.
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