Voprosy meditsinskoi khimii (ISSN 0042-8809)

Comparative effects of the partial opiate agonistsbuprenorphine and butorphanol on the phospholipid composition of liver cell plasmamembranes under hemorrhagic shock in cats

   


1. Research Institute of General Pathology and Pathophysiology
PubMed Id: 12498093
Year: 2002 vol: 48  issue:5  pages: 497-502
Abstract: Comparative effects of the partialopiate agonists buprenorphine and butorphanol on the phospholipid composition of livercell plasma membranes were investigated in cats under conditions of hemorrhagic shock.Buprenorphine administration (0.03 mg/kg) normalized the level of phosphatidylinositol.The higher dose (0.3 mg/kg) induced additional disturbances in the phospholipidcomposition of liver cell plasma membranes by increasing the content of phosphatidylserineand by decreasing the contents of sphingomyelin and lysophosphatidylcholine. Theprotective effect of butorphanol on liver cells was more pronounced than that ofbuprenorphine.
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Reference: Leskova G.F., Arkhipenko Yu.V., Comparative effects of the partial opiate agonistsbuprenorphine and butorphanol on the phospholipid composition of liver cell plasmamembranes under hemorrhagic shock in cats, Voprosy meditsinskoi khimii, 2002, vol: 48(5), 497-502.
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